6ZS1

Chaetomium thermophilum CuZn-superoxide dismutase

Summary for 6ZS1

• Entry DOI: 10.2210/pdb6zs1/pdb
• Descriptor: Superoxide dismutase [Cu-Zn], ZINC ION, PHOSPHATE ION, ... (7 entities in total)
• Functional Keywords: thermophilic fungus, superoxide, antioxidant, thermostability, metalloenzyme, metal-binding protein, metal binding protein
• Biological source: Chaetomium thermophilum var. thermophilum DSM 1495
• Total number of polymer chains: 8
• Total formula weight: 133107.74

Authors

Papageorgiou, A.C.,Mohsin, I. (deposition date: 2020-07-15, release date: 2021-04-07, Last modification date: 2024-10-16)

Primary citation

Mohsin, I.,Zhang, L.Q.,Li, D.C.,Papageorgiou, A.C.
Crystal Structure of a Cu,Zn Superoxide Dismutase From the Thermophilic Fungus Chaetomium thermophilum.
Protein Pept.Lett., 28:1043-1053, 2021

PubMed Abstract: Thermophilic fungi have recently emerged as a promising source of thermostable enzymes. Superoxide dismutases are key antioxidant metalloenzymes with promising therapeutic effects in various diseases, both acute and chronic. However, structural heterogeneity and low thermostability limit their therapeutic efficacy.

PubMed: 33726638
DOI: 10.2174/0929866528666210316104919

Experimental method

X-RAY DIFFRACTION (1.56 Å)