6ZS1

Chaetomium thermophilum CuZn-superoxide dismutase

6ZS1 の概要

• エントリーDOI: 10.2210/pdb6zs1/pdb
• 分子名称: Superoxide dismutase [Cu-Zn], ZINC ION, PHOSPHATE ION, ... (7 entities in total)
• 機能のキーワード: thermophilic fungus, superoxide, antioxidant, thermostability, metalloenzyme, metal-binding protein, metal binding protein
• 由来する生物種: Chaetomium thermophilum var. thermophilum DSM 1495
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 133107.74

構造登録者

Papageorgiou, A.C.,Mohsin, I. (登録日: 2020-07-15, 公開日: 2021-04-07, 最終更新日: 2024-10-16)

主引用文献

Mohsin, I.,Zhang, L.Q.,Li, D.C.,Papageorgiou, A.C.
Crystal Structure of a Cu,Zn Superoxide Dismutase From the Thermophilic Fungus Chaetomium thermophilum.
Protein Pept.Lett., 28:1043-1053, 2021

PubMed Abstract: Thermophilic fungi have recently emerged as a promising source of thermostable enzymes. Superoxide dismutases are key antioxidant metalloenzymes with promising therapeutic effects in various diseases, both acute and chronic. However, structural heterogeneity and low thermostability limit their therapeutic efficacy.

PubMed: 33726638
DOI: 10.2174/0929866528666210316104919

実験手法

X-RAY DIFFRACTION (1.56 Å)