6ZRC

Structure of the human RBAP48 in complex with a macrocyclic peptide cyclized via a xylene linker attached to two cysteines

Summary for 6ZRC

• Entry DOI: 10.2210/pdb6zrc/pdb
• Descriptor: Histone-binding protein RBBP4, macrocyclic peptide based on residues 659-672 of the metastasis-associated protein MTA1, PARA-XYLENE, ... (4 entities in total)
• Functional Keywords: nurd, histone binding domain, wd40 domain, beta propeller, chromatin regulator, macrocyclic peptide, cell cycle
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 99239.77

Authors

Vetter, I.R.,Porfetye, A.T. (deposition date: 2020-07-13, release date: 2020-10-28, Last modification date: 2024-01-31)

• Primary citation: Hart, P.'.,Hommen, P.,Noisier, A.,Krzyzanowski, A.,Schuler, D.,Porfetye, A.T.,Akbarzadeh, M.,Vetter, I.R.,Adihou, H.,Waldmann, H.; Structure Based Design of Bicyclic Peptide Inhibitors of RbAp48.; Angew.Chem.Int.Ed.Engl., 60:1813-1820, 2021; PubMed: 33022847; DOI: 10.1002/anie.202009749

Experimental method

X-RAY DIFFRACTION (2.6 Å)