6ZRC

Structure of the human RBAP48 in complex with a macrocyclic peptide cyclized via a xylene linker attached to two cysteines

6ZRC の概要

• エントリーDOI: 10.2210/pdb6zrc/pdb
• 分子名称: Histone-binding protein RBBP4, macrocyclic peptide based on residues 659-672 of the metastasis-associated protein MTA1, PARA-XYLENE, ... (4 entities in total)
• 機能のキーワード: nurd, histone binding domain, wd40 domain, beta propeller, chromatin regulator, macrocyclic peptide, cell cycle
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 99239.77

構造登録者

Vetter, I.R.,Porfetye, A.T. (登録日: 2020-07-13, 公開日: 2020-10-28, 最終更新日: 2024-01-31)

• 主引用文献: Hart, P.'.,Hommen, P.,Noisier, A.,Krzyzanowski, A.,Schuler, D.,Porfetye, A.T.,Akbarzadeh, M.,Vetter, I.R.,Adihou, H.,Waldmann, H.; Structure Based Design of Bicyclic Peptide Inhibitors of RbAp48.; Angew.Chem.Int.Ed.Engl., 60:1813-1820, 2021; PubMed: 33022847; DOI: 10.1002/anie.202009749

実験手法

X-RAY DIFFRACTION (2.6 Å)