6ZOS

Oestrogen receptor ligand binding domain in complex with compound 18

6ZOS の概要

• エントリーDOI: 10.2210/pdb6zos/pdb
• 分子名称: Estrogen receptor, 6-[(6~{S},8~{R})-7-[(1-fluoranylcyclopropyl)methyl]-8-methyl-2,6,8,9-tetrahydropyrazolo[4,3-f]isoquinolin-6-yl]-~{N}-[1-(3-fluoranylpropyl)azetidin-3-yl]pyridin-3-amine (3 entities in total)
• 機能のキーワード: oestrogen receptor, gene regulation
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 58244.18

構造登録者

Breed, J. (登録日: 2020-07-07, 公開日: 2021-01-20, 最終更新日: 2024-01-31)

• 主引用文献: Scott, J.S.,Moss, T.A.,Balazs, A.,Barlaam, B.,Breed, J.,Carbajo, R.J.,Chiarparin, E.,Davey, P.R.J.,Delpuech, O.,Fawell, S.,Fisher, D.I.,Gagrica, S.,Gangl, E.T.,Grebe, T.,Greenwood, R.D.,Hande, S.,Hatoum-Mokdad, H.,Herlihy, K.,Hughes, S.,Hunt, T.A.,Huynh, H.,Janbon, S.L.M.,Johnson, T.,Kavanagh, S.,Klinowska, T.,Lawson, M.,Lister, A.S.,Marden, S.,McGinnity, D.F.,Morrow, C.J.,Nissink, J.W.M.,O'Donovan, D.H.,Peng, B.,Polanski, R.,Stead, D.S.,Stokes, S.,Thakur, K.,Throner, S.R.,Tucker, M.J.,Varnes, J.,Wang, H.,Wilson, D.M.,Wu, D.,Wu, Y.,Yang, B.,Yang, W.; Discovery of AZD9833, a Potent and Orally Bioavailable Selective Estrogen Receptor Degrader and Antagonist.; J.Med.Chem., 63:14530-14559, 2020; PubMed: 32910656; DOI: 10.1021/acs.jmedchem.0c01163

実験手法

X-RAY DIFFRACTION (2 Å)