6ZLR

Soaking competent crystal form of the SARS-CoV-2 Receptor Binding Domain (RBD):CR3022 complex.

これはPDB形式変換不可エントリーです。

6ZLR の概要

• エントリーDOI: 10.2210/pdb6zlr/pdb
• 分子名称: Spike glycoprotein, CR3022 FAB HEAVY CHAIN, CR3022 FAB LIGHT CHAIN, ... (4 entities in total)
• 機能のキーワード: sars-cov-2, viral protein complex, antibody, viral protein
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV); 詳細
• タンパク質・核酸の鎖数: 9
• 化学式量合計: 222446.82

構造登録者

de Nicola, G.F.,Nichols, C.E. (登録日: 2020-07-01, 公開日: 2020-12-23, 最終更新日: 2024-10-23)

主引用文献

Nichols, C.,Ng, J.,Keshu, A.,Fraternali, F.,De Nicola, G.F.
A New Crystal Form of the SARS-CoV-2 Receptor Binding Domain: CR3022 Complex-An Ideal Target for In-Crystal Fragment Screening of the ACE2 Binding Site Surface.
Front Pharmacol, 11:615211-615211, 2020

PubMed Abstract: In-crystal fragment screening is a powerful tool to chemically probe the surfaces used by proteins to interact, and identify the chemical space worth exploring to design protein-protein inhibitors. A crucial prerequisite is the identification of a crystal form where the target area is exposed and accessible to be probed by fragments. Here we report a crystal form of the SARS-CoV-2 Receptor Binding Domain in complex with the CR3022 antibody where the ACE2 binding site on the Receptor Binding Domain is exposed and accessible. This crystal form of the complex is a valuable tool to develop antiviral molecules that could act by blocking the virus entry in cells.

PubMed: 33381049
DOI: 10.3389/fphar.2020.615211

実験手法

X-RAY DIFFRACTION (3.1 Å)