6ZK7

Crystal Structure of human PYROXD1/FAD complex

This is a non-PDB format compatible entry.

Summary for 6ZK7

• Entry DOI: 10.2210/pdb6zk7/pdb
• Descriptor: Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1, FLAVIN-ADENINE DINUCLEOTIDE (2 entities in total)
• Functional Keywords: redox regulation, nad(p)(h) binding, trna ligase complex, flavoprotein, oxidoreductase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 57763.12

Authors

Meinhart, A.,Asanovic, I.,Martinez, J.,Clausen, T. (deposition date: 2020-06-30, release date: 2021-05-12, Last modification date: 2024-01-31)

• Primary citation: Asanovic, I.,Strandback, E.,Kroupova, A.,Pasajlic, D.,Meinhart, A.,Tsung-Pin, P.,Djokovic, N.,Anrather, D.,Schuetz, T.,Suskiewicz, M.J.,Sillamaa, S.,Kocher, T.,Beveridge, R.,Nikolic, K.,Schleiffer, A.,Jinek, M.,Hartl, M.,Clausen, T.,Penninger, J.,Macheroux, P.,Weitzer, S.,Martinez, J.; The oxidoreductase PYROXD1 uses NAD(P) + as an antioxidant to sustain tRNA ligase activity in pre-tRNA splicing and unfolded protein response.; Mol.Cell, 81:2520-, 2021; PubMed: 33930333; DOI: 10.1016/j.molcel.2021.04.007

Experimental method

X-RAY DIFFRACTION (3.2 Å)