Summary for 6ZK7
Entry DOI | 10.2210/pdb6zk7/pdb |
Descriptor | Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1, FLAVIN-ADENINE DINUCLEOTIDE (2 entities in total) |
Functional Keywords | redox regulation, nad(p)(h) binding, trna ligase complex, flavoprotein, oxidoreductase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 57763.12 |
Authors | Meinhart, A.,Asanovic, I.,Martinez, J.,Clausen, T. (deposition date: 2020-06-30, release date: 2021-05-12, Last modification date: 2024-01-31) |
Primary citation | Asanovic, I.,Strandback, E.,Kroupova, A.,Pasajlic, D.,Meinhart, A.,Tsung-Pin, P.,Djokovic, N.,Anrather, D.,Schuetz, T.,Suskiewicz, M.J.,Sillamaa, S.,Kocher, T.,Beveridge, R.,Nikolic, K.,Schleiffer, A.,Jinek, M.,Hartl, M.,Clausen, T.,Penninger, J.,Macheroux, P.,Weitzer, S.,Martinez, J. The oxidoreductase PYROXD1 uses NAD(P) + as an antioxidant to sustain tRNA ligase activity in pre-tRNA splicing and unfolded protein response. Mol.Cell, 81:2520-, 2021 Cited by PubMed: 33930333DOI: 10.1016/j.molcel.2021.04.007 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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