6ZJ0
CRYSTAL STRUCTURE OF HRAS-G12D IN COMPLEX WITH GCP AND COMPOUND 18
Summary for 6ZJ0
| Entry DOI | 10.2210/pdb6zj0/pdb |
| Descriptor | GTPase HRas, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ... (5 entities in total) |
| Functional Keywords | gtpase, hydrolase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 19881.47 |
| Authors | Kessler, D.,Fischer, G.,Boettcher, J. (deposition date: 2020-06-26, release date: 2020-08-19, Last modification date: 2024-01-31) |
| Primary citation | Kessler, D.,Bergner, A.,Bottcher, J.,Fischer, G.,Dobel, S.,Hinkel, M.,Mullauer, B.,Weiss-Puxbaum, A.,McConnell, D.B. Drugging all RAS isoforms with one pocket. Future Med Chem, 12:1911-1923, 2020 Cited by PubMed: 32779487DOI: 10.4155/fmc-2020-0221 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.763 Å) |
Structure validation
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