6ZE1

human NBD1 of CFTR in complex with nanobody G11a

Summary for 6ZE1

Entry DOI	10.2210/pdb6ze1/pdb
Descriptor	Cystic fibrosis transmembrane conductance regulator, G11a nanobody, ADENOSINE-5'-TRIPHOSPHATE, ... (6 entities in total)
Functional Keywords	cystic fibrosis, cftr, nanobodies, allostery, conformational change, hydrolase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	46164.52
Authors	Garcia-Pino, A.,Govaerts, C.,Scholl, D.,Sigoillot, M. (deposition date: 2020-06-15, release date: 2021-06-30, Last modification date: 2024-01-24)
Primary citation	Scholl, D.,Sigoillot, M.,Overtus, M.,Martinez, R.C.,Martens, C.,Wang, Y.,Pardon, E.,Laeremans, T.,Garcia-Pino, A.,Steyaert, J.,Sheppard, D.N.,Hendrix, J.,Govaerts, C. A topological switch in CFTR modulates channel activity and sensitivity to unfolding. Nat.Chem.Biol., 17:989-997, 2021 Cited by PubMed: 34341587 DOI: 10.1038/s41589-021-00844-0 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.705 Å)

Structure validation