6ZDV

Crystal structure of stabilized A2A adenosine receptor A2AR-StaR2-bRIL in complex with Chromone 5d

6ZDV の概要

• エントリーDOI: 10.2210/pdb6zdv/pdb
• 関連するPDBエントリー: 6ZRD
• 分子名称: Adenosine receptor A2a,Soluble cytochrome b562,Adenosine receptor A2a, [2-methyl-3-(4-methyl-1,3-thiazol-2-yl)-4-oxidanylidene-6-propyl-chromen-7-yl] ethanoate, SODIUM ION, ... (8 entities in total)
• 機能のキーワード: g protein-coupled receptor, membrane protein, receptor, protein binding
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 54204.65

構造登録者

Verdon, G.,Jespers, W.,Azuaje, J.,Majellaro, M.,Keranen, H.,Garcia-mera, X.,Congreve, M.,Deflorian, F.,de Graaf, C.,Zhukov, A.,Dore, A.,Mason, J.,Aqvist, J.,Cooke, R.,Sotelo, E.,Gutierrez-de-Teran, H. (登録日: 2020-06-15, 公開日: 2020-09-16, 最終更新日: 2024-01-24)

• 主引用文献: Jespers, W.,Verdon, G.,Azuaje, J.,Majellaro, M.,Keranen, H.,Garcia-Mera, X.,Congreve, M.,Deflorian, F.,de Graaf, C.,Zhukov, A.,Dore, A.S.,Mason, J.S.,Aqvist, J.,Cooke, R.M.,Sotelo, E.,Gutierrez-de-Teran, H.; X-Ray Crystallography and Free Energy Calculations Reveal the Binding Mechanism of A 2A Adenosine Receptor Antagonists.; Angew.Chem.Int.Ed.Engl., 59:16536-16543, 2020; PubMed: 32542862; DOI: 10.1002/anie.202003788

実験手法

X-RAY DIFFRACTION (2.13 Å)