6ZCL

Coxsackievirus B3 in complex with capsid binder compound 17

6ZCL の概要

• エントリーDOI: 10.2210/pdb6zcl/pdb
• EMDBエントリー: 11166
• 分子名称: capsid protein VP1, capsid protein VP2, capsid protein VP3, ... (6 entities in total)
• 機能のキーワード: enterovirus, coxackievirus b4, capsid binder, inhibitor, virus
• 由来する生物種: Coxsackievirus B3 (strain Nancy); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 92040.69

構造登録者

Domanska, A.,Flatt, J.W.,Butcher, S.J. (登録日: 2020-06-11, 公開日: 2021-03-17, 最終更新日: 2024-10-23)

主引用文献

Flatt, J.W.,Domanska, A.,Seppala, A.L.,Butcher, S.J.
Identification of a conserved virion-stabilizing network inside the interprotomer pocket of enteroviruses.
Commun Biol, 4:250-250, 2021

PubMed Abstract: Enteroviruses pose a persistent and widespread threat to human physical health, with no specific treatments available. Small molecule capsid binders have the potential to be developed as antivirals that prevent virus attachment and entry into host cells. To aid with broad-range drug development, we report here structures of coxsackieviruses B3 and B4 bound to different interprotomer-targeting capsid binders using single-particle cryo-EM. The EM density maps are beyond 3 Å resolution, providing detailed information about interactions in the ligand-binding pocket. Comparative analysis revealed the residues that form a conserved virion-stabilizing network at the interprotomer site, and showed the small molecule properties that allow anchoring in the pocket to inhibit virus disassembly.

PubMed: 33637854
DOI: 10.1038/s42003-021-01779-x

実験手法

ELECTRON MICROSCOPY (2.8 Å)