6ZAA

PI3K Delta in complex with methoxy(methylsulfamoyl)pyridinylN(methylpiperidinyl)dihydrobenzoxazinecarboxamide

6ZAA の概要

• エントリーDOI: 10.2210/pdb6zaa/pdb
• 分子名称: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, 4-[6-methoxy-5-(methylsulfamoyl)pyridin-3-yl]-~{N}-(1-methylpiperidin-4-yl)-2,3-dihydro-1,4-benzoxazine-6-carboxamide (3 entities in total)
• 機能のキーワード: macrocycle, pi3k delta, thermodynamics, transferase
• 由来する生物種: Mus musculus (Mouse)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 108299.23

構造登録者

Convery, M.A.,Hardy, C.J.,Spencer, J.A.,Rowland, P. (登録日: 2020-06-05, 公開日: 2020-07-15, 最終更新日: 2024-06-19)

• 主引用文献: Spencer, J.A.,Baldwin, I.R.,Barton, N.,Chung, C.W.,Convery, M.A.,Edwards, C.D.,Jamieson, C.,Mallett, D.N.,Rowedder, J.E.,Rowland, P.,Thomas, D.A.,Hardy, C.J.; Design and Development of a Macrocyclic Series Targeting Phosphoinositide 3-Kinase delta.; Acs Med.Chem.Lett., 11:1386-1391, 2020; PubMed: 32676144; DOI: 10.1021/acsmedchemlett.0c00061

実験手法

X-RAY DIFFRACTION (2.52 Å)