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6Z7K

Crystal structure of CTX-M-15 in complex with the imine form of hydrolysed tazobactam

Summary for 6Z7K
Entry DOI10.2210/pdb6z7k/pdb
DescriptorBeta-lactamase, (2~{S},3~{S})-3-[bis(oxidanylidene)-$l^{5}-sulfanyl]-3-methyl-2-[(~{E})-3-oxidanylidenepropylideneamino]-4-(1,2,3-triaz ol-1-yl)butanoic acid, SULFATE ION, ... (5 entities in total)
Functional Keywordsbeta-lactamase, inhibitor, antibiotic resistance, antimicrobial protein
Biological sourceKlebsiella pneumoniae
Total number of polymer chains1
Total formula weight28837.87
Authors
Tooke, C.L.,Hinchliffe, P.,Spencer, J. (deposition date: 2020-05-31, release date: 2021-06-09, Last modification date: 2024-01-24)
Primary citationHinchliffe, P.,Tooke, C.L.,Bethel, C.R.,Wang, B.,Arthur, C.,Heesom, K.J.,Shapiro, S.,Schlatzer, D.M.,Papp-Wallace, K.M.,Bonomo, R.A.,Spencer, J.
Penicillanic Acid Sulfones Inactivate the Extended-Spectrum beta-Lactamase CTX-M-15 through Formation of a Serine-Lysine Cross-Link: an Alternative Mechanism of beta-Lactamase Inhibition.
Mbio, :e0179321-e0179321, 2022
Cited by
PubMed: 35612361
DOI: 10.1128/mbio.01793-21
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.1 Å)
Structure validation

221051

數據於2024-06-12公開中

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