6Z7K

Crystal structure of CTX-M-15 in complex with the imine form of hydrolysed tazobactam

6Z7K の概要

• エントリーDOI: 10.2210/pdb6z7k/pdb
• 分子名称: Beta-lactamase, (2~{S},3~{S})-3-[bis(oxidanylidene)-$l^{5}-sulfanyl]-3-methyl-2-[(~{E})-3-oxidanylidenepropylideneamino]-4-(1,2,3-triaz ol-1-yl)butanoic acid, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: beta-lactamase, inhibitor, antibiotic resistance, antimicrobial protein
• 由来する生物種: Klebsiella pneumoniae
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 28837.87

構造登録者

Tooke, C.L.,Hinchliffe, P.,Spencer, J. (登録日: 2020-05-31, 公開日: 2021-06-09, 最終更新日: 2024-01-24)

• 主引用文献: Hinchliffe, P.,Tooke, C.L.,Bethel, C.R.,Wang, B.,Arthur, C.,Heesom, K.J.,Shapiro, S.,Schlatzer, D.M.,Papp-Wallace, K.M.,Bonomo, R.A.,Spencer, J.; Penicillanic Acid Sulfones Inactivate the Extended-Spectrum beta-Lactamase CTX-M-15 through Formation of a Serine-Lysine Cross-Link: an Alternative Mechanism of beta-Lactamase Inhibition.; Mbio, :e0179321-e0179321, 2022; PubMed: 35612361; DOI: 10.1128/mbio.01793-21

実験手法

X-RAY DIFFRACTION (1.1 Å)