6Z7H

Structure of CTX-M-15 E166Q mutant crystallised in the presence of enmetazobactam (AAI101)

Summary for 6Z7H

• Entry DOI: 10.2210/pdb6z7h/pdb
• Descriptor: Beta-lactamase, SULFATE ION, GLYCEROL, ... (5 entities in total)
• Functional Keywords: beta-lactamase, inhibitor, antibiotic resistance, cross-link, antimicrobial protein
• Biological source: Klebsiella pneumoniae IS53
• Total number of polymer chains: 1
• Total formula weight: 28787.80

Authors

Tooke, C.L.,Hinchliffe, P.,Spencer, J. (deposition date: 2020-05-31, release date: 2021-06-09, Last modification date: 2024-01-24)

• Primary citation: Hinchliffe, P.,Tooke, C.L.,Bethel, C.R.,Wang, B.,Arthur, C.,Heesom, K.J.,Shapiro, S.,Schlatzer, D.M.,Papp-Wallace, K.M.,Bonomo, R.A.,Spencer, J.; Penicillanic Acid Sulfones Inactivate the Extended-Spectrum beta-Lactamase CTX-M-15 through Formation of a Serine-Lysine Cross-Link: an Alternative Mechanism of beta-Lactamase Inhibition.; Mbio, :e0179321-e0179321, 2022; PubMed: 35612361; DOI: 10.1128/mbio.01793-21

Experimental method

X-RAY DIFFRACTION (1.42 Å)