6Z79

Variant Surface Glycoprotein VSGsur, I3C ("Magic Triangle") derivative used for phasing of the structure and subsequently as a model for molecular replacement of native, mutants, and drug soaks.

6Z79 の概要

• エントリーDOI: 10.2210/pdb6z79/pdb
• 分子名称: Variant surface glycoprotein Sur, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-amino-2,4,6-triiodobenzene-1,3-dicarboxylic acid, ... (4 entities in total)
• 機能のキーワード: variant surface glycoprotein suramin trypanosomiasis drug resistance glycosylation magic triangle i3c, membrane protein
• 由来する生物種: Trypanosoma brucei rhodesiense
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 53937.74

構造登録者

Zeelen, J.P.,Straaten van, M.,Stebbins, C.E. (登録日: 2020-05-30, 公開日: 2021-03-17)

• 主引用文献: Zeelen, J.,van Straaten, M.,Verdi, J.,Hempelmann, A.,Hashemi, H.,Perez, K.,Jeffrey, P.D.,Halg, S.,Wiedemar, N.,Maser, P.,Papavasiliou, F.N.,Stebbins, C.E.; Structure of trypanosome coat protein VSGsur and function in suramin resistance.; Nat Microbiol, 6:392-400, 2021; PubMed: 33462435; DOI: 10.1038/s41564-020-00844-1

実験手法

X-RAY DIFFRACTION (1.92 Å)