6Z4B

Crystal Structure of EGFR-T790M/V948R in Complex with Osimertinib and EAI045

Summary for 6Z4B

Entry DOI	10.2210/pdb6z4b/pdb
Descriptor	Epidermal growth factor receptor, ~{N}-[2-[2-(dimethylamino)ethyl-methyl-amino]-4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]propanamide, (2R)-2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)-N-(1,3-thiazol-2-yl)acetamide, ... (5 entities in total)
Functional Keywords	egfr, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	78658.49
Authors	Niggenaber, J.,Mueller, M.P.,Rauh, D. (deposition date: 2020-05-25, release date: 2020-11-11, Last modification date: 2024-01-24)
Primary citation	Niggenaber, J.,Heyden, L.,Grabe, T.,Muller, M.P.,Lategahn, J.,Rauh, D. Complex Crystal Structures of EGFR with Third-Generation Kinase Inhibitors and Simultaneously Bound Allosteric Ligands. Acs Med.Chem.Lett., 11:2484-2490, 2020 Cited by PubMed: 33335671 DOI: 10.1021/acsmedchemlett.0c00472 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation