6Z4B

Crystal Structure of EGFR-T790M/V948R in Complex with Osimertinib and EAI045

6Z4B の概要

• エントリーDOI: 10.2210/pdb6z4b/pdb
• 分子名称: Epidermal growth factor receptor, ~{N}-[2-[2-(dimethylamino)ethyl-methyl-amino]-4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]propanamide, (2R)-2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)-N-(1,3-thiazol-2-yl)acetamide, ... (5 entities in total)
• 機能のキーワード: egfr, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 78658.49

構造登録者

Niggenaber, J.,Mueller, M.P.,Rauh, D. (登録日: 2020-05-25, 公開日: 2020-11-11, 最終更新日: 2024-01-24)

• 主引用文献: Niggenaber, J.,Heyden, L.,Grabe, T.,Muller, M.P.,Lategahn, J.,Rauh, D.; Complex Crystal Structures of EGFR with Third-Generation Kinase Inhibitors and Simultaneously Bound Allosteric Ligands.; Acs Med.Chem.Lett., 11:2484-2490, 2020; PubMed: 33335671; DOI: 10.1021/acsmedchemlett.0c00472

実験手法

X-RAY DIFFRACTION (2.5 Å)