6Z24
Acylenzyme complex of ceftazidime bound to deacylation mutant KPC-2 (E166Q)
Summary for 6Z24
Entry DOI | 10.2210/pdb6z24/pdb |
Descriptor | Carbapenem-hydrolyzing beta-lactamase KPC, ACYLATED CEFTAZIDIME, SULFATE ION, ... (4 entities in total) |
Functional Keywords | unliganded beta-lactamase, 3-layer alpha-beta-alpha sandwich, part of the dd-peptidase and beta-lactamase superfamily., antimicrobial protein |
Biological source | Klebsiella pneumoniae |
Total number of polymer chains | 1 |
Total formula weight | 31563.33 |
Authors | Tooke, C.L.,Hinchliffe, P.,Spencer, J. (deposition date: 2020-05-14, release date: 2020-12-23, Last modification date: 2024-01-24) |
Primary citation | Tooke, C.L.,Hinchliffe, P.,Bonomo, R.A.,Schofield, C.J.,Mulholland, A.J.,Spencer, J. Natural variants modify Klebsiella pneumoniae carbapenemase (KPC) acyl-enzyme conformational dynamics to extend antibiotic resistance. J.Biol.Chem., 296:100126-100126, 2020 Cited by PubMed: 33257320DOI: 10.1074/jbc.RA120.016461 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.25 Å) |
Structure validation
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