6Z23

Acylenzyme complex of cefotaxime bound to deacylation mutant KPC-2 (E166Q)

6Z23 の概要

• エントリーDOI: 10.2210/pdb6z23/pdb
• 分子名称: Carbapenem-hydrolyzing beta-lactamase KPC, GLYCEROL, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: unliganded beta-lactamase, 3-layer alpha-beta-alpha sandwich, part of the dd-peptidase and beta-lactamase superfamily., antimicrobial protein
• 由来する生物種: Klebsiella pneumoniae
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 31867.58

構造登録者

Tooke, C.L.,Hinchliffe, P.,Spencer, J. (登録日: 2020-05-14, 公開日: 2020-12-23, 最終更新日: 2024-01-24)

• 主引用文献: Tooke, C.L.,Hinchliffe, P.,Bonomo, R.A.,Schofield, C.J.,Mulholland, A.J.,Spencer, J.; Natural variants modify Klebsiella pneumoniae carbapenemase (KPC) acyl-enzyme conformational dynamics to extend antibiotic resistance.; J.Biol.Chem., 296:100126-100126, 2020; PubMed: 33257320; DOI: 10.1074/jbc.RA120.016461

実験手法

X-RAY DIFFRACTION (1.31 Å)