6Z0R
Crystal structure of SAICAR Synthetase (PurC) from Mycobacterium abscessus in complex with fragment 1
Summary for 6Z0R
Entry DOI | 10.2210/pdb6z0r/pdb |
Descriptor | Phosphoribosylaminoimidazole-succinocarboxamide synthase, 4-azanylpyrimidine-5-carbonitrile, SULFATE ION, ... (5 entities in total) |
Functional Keywords | saicar synthetase, phosphoribosylaminoimidazole-succinocarboxamide synthase, purc, purine biosynthesis, ligase |
Biological source | Mycobacteroides abscessus ATCC 19977 |
Total number of polymer chains | 1 |
Total formula weight | 34240.49 |
Authors | Thomas, S.E.,Charoensutthivarakul, S.,Coyne, A.G.,Abell, C.,Blundell, T.L. (deposition date: 2020-05-10, release date: 2021-05-19, Last modification date: 2024-01-24) |
Primary citation | Charoensutthivarakul, S.,Thomas, S.E.,Curran, A.,Brown, K.P.,Belardinelli, J.M.,Whitehouse, A.J.,Acebron-Garcia-de-Eulate, M.,Sangan, J.,Gramani, S.G.,Jackson, M.,Mendes, V.,Floto, R.A.,Blundell, T.L.,Coyne, A.G.,Abell, C. Development of Inhibitors of SAICAR Synthetase (PurC) from Mycobacterium abscessus Using a Fragment-Based Approach. Acs Infect Dis., 8:296-309, 2022 Cited by PubMed: 35037462DOI: 10.1021/acsinfecdis.1c00432 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.308 Å) |
Structure validation
Download full validation report![Download](/newweb/media/icons/dl.png)
![Download](/newweb/media/icons/dl.png)