6YYC
Crystal structure of SAICAR Synthetase (PurC) from Mycobacterium abscessus in complex with inhibitor
6YYC の概要
エントリーDOI | 10.2210/pdb6yyc/pdb |
分子名称 | Phosphoribosylaminoimidazole-succinocarboxamide synthase, 5-chloranyl-6-[1-[(3-fluorophenyl)methyl]pyrazol-4-yl]pyrimidin-4-amine, SULFATE ION, ... (5 entities in total) |
機能のキーワード | saicar synthetase, phosphoribosylaminoimidazole-succinocarboxamide synthase, purc, purine biosynthesis, ligase |
由来する生物種 | Mycobacteroides abscessus (strain ATCC 19977 / DSM 44196 / CIP 104536 / JCM 13569 / NCTC 13031 / TMC 1543) |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 34362.03 |
構造登録者 | Thomas, S.E.,Charoensutthivarakul, S.,Coyne, A.G.,Abell, C.,Blundell, T.L. (登録日: 2020-05-04, 公開日: 2021-05-12, 最終更新日: 2024-01-24) |
主引用文献 | Charoensutthivarakul, S.,Thomas, S.E.,Curran, A.,Brown, K.P.,Belardinelli, J.M.,Whitehouse, A.J.,Acebron-Garcia-de-Eulate, M.,Sangan, J.,Gramani, S.G.,Jackson, M.,Mendes, V.,Floto, R.A.,Blundell, T.L.,Coyne, A.G.,Abell, C. Development of Inhibitors of SAICAR Synthetase (PurC) from Mycobacterium abscessus Using a Fragment-Based Approach. Acs Infect Dis., 8:296-309, 2022 Cited by PubMed: 35037462DOI: 10.1021/acsinfecdis.1c00432 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.274 Å) |
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