6YX3

Crystal structure of SAICAR Synthetase (PurC) from Mycobacterium abscessus in complex with ATP

6YX3 の概要

• エントリーDOI: 10.2210/pdb6yx3/pdb
• 分子名称: Phosphoribosylaminoimidazole-succinocarboxamide synthase, SULFATE ION, MAGNESIUM ION, ... (5 entities in total)
• 機能のキーワード: saicar synthetase, phosphoribosylaminoimidazole-succinocarboxamide synthase, purc, purine biosynthesis, ligase
• 由来する生物種: Mycobacteroides abscessus (strain ATCC 19977 / DSM 44196 / CIP 104536 / JCM 13569 / NCTC 13031 / TMC 1543)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34719.85

構造登録者

Thomas, S.E.,Charoensutthivarakul, S.,Coyne, A.G.,Abell, C.,Blundell, T.L. (登録日: 2020-04-30, 公開日: 2021-05-12, 最終更新日: 2024-01-24)

• 主引用文献: Charoensutthivarakul, S.,Thomas, S.E.,Curran, A.,Brown, K.P.,Belardinelli, J.M.,Whitehouse, A.J.,Acebron-Garcia-de-Eulate, M.,Sangan, J.,Gramani, S.G.,Jackson, M.,Mendes, V.,Floto, R.A.,Blundell, T.L.,Coyne, A.G.,Abell, C.; Development of Inhibitors of SAICAR Synthetase (PurC) from Mycobacterium abscessus Using a Fragment-Based Approach.; Acs Infect Dis., 8:296-309, 2022; PubMed: 35037462; DOI: 10.1021/acsinfecdis.1c00432

実験手法

X-RAY DIFFRACTION (1.22 Å)