6YRS

Structure of a new variant of GNCA ancestral beta-lactamase

6YRS の概要

• エントリーDOI: 10.2210/pdb6yrs/pdb
• 分子名称: ancestral beta-lactamase, ACETATE ION, TRIETHYLENE GLYCOL, ... (7 entities in total)
• 機能のキーワード: hydrolase, antibiotic resistance, ancestral reconstructed
• 由来する生物種: synthetic construct
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 59679.80

構造登録者

Gavira, J.A.,Risso, V.,Martinez-Rodriguez, S.,Sanchez-Ruiz, J.M.,Modi, T.,Ozkan, S.B. (登録日: 2020-04-20, 公開日: 2021-03-03, 最終更新日: 2024-01-24)

• 主引用文献: Modi, T.,Risso, V.A.,Martinez-Rodriguez, S.,Gavira, J.A.,Mebrat, M.D.,Van Horn, W.D.,Sanchez-Ruiz, J.M.,Banu Ozkan, S.; Hinge-shift mechanism as a protein design principle for the evolution of beta-lactamases from substrate promiscuity to specificity.; Nat Commun, 12:1852-1852, 2021; PubMed: 33767175; DOI: 10.1038/s41467-021-22089-0

実験手法

X-RAY DIFFRACTION (1.7 Å)