6YQT

CRYSTAL STRUCTURE OF HUMAN CA II IN COMPLEX WITH A SULFONAMIDE DERIVATIVE OF 2-MERCAPTOBENZOXAZOLE

6YQT の概要

• エントリーDOI: 10.2210/pdb6yqt/pdb
• 分子名称: Carbonic anhydrase 2, ZINC ION, 2-sulfanylidene-3~{H}-1,3-benzoxazole-5-sulfonamide, ... (5 entities in total)
• 機能のキーワード: 2-mercaptobenzoxazole-5-sulfonamide, carbonic anhydrase, inhibitor complex, lyase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29893.13

構造登録者

Alterio, V.,De Simone, G.,Esposito, D. (登録日: 2020-04-18, 公開日: 2020-07-01, 最終更新日: 2024-01-24)

• 主引用文献: Bozdag, M.,Supuran, C.T.,Esposito, D.,Angeli, A.,Carta, F.,Monti, S.M.,De Simone, G.,Alterio, V.; 2-Mercaptobenzoxazoles: a class of carbonic anhydrase inhibitors with a novel binding mode to the enzyme active site.; Chem.Commun.(Camb.), 56:8297-8300, 2020; PubMed: 32573627; DOI: 10.1039/d0cc02857f

実験手法

X-RAY DIFFRACTION (1.5 Å)