6YL8

Crystal structure of YTHDC1 with compound DHU_DC1_011

Summary for 6YL8

• Entry DOI: 10.2210/pdb6yl8/pdb
• Descriptor: YTHDC1, (2~{R},5~{S})-2-(2-chlorophenyl)-5-methyl-morpholine, SULFATE ION, ... (4 entities in total)
• Functional Keywords: ythdc1, m6a, complex, inhibitor, rna binding protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 43337.89

Authors

Bedi, R.K.,Huang, D.,Wiedmer, L.,Caflisch, A. (deposition date: 2020-04-06, release date: 2020-07-15, Last modification date: 2024-01-24)

• Primary citation: Li, Y.,Bedi, R.K.,Nai, F.,von Roten, V.,Dolbois, A.,Zalesak, F.,Nachawati, R.,Huang, D.,Caflisch, A.; Structure-based design of ligands of the m6A-RNA reader YTHDC1; Eur J Med Chem Rep, 5:100057-, 2022; DOI: 10.1016/j.ejmcr.2022.100057

Experimental method

X-RAY DIFFRACTION (1.5 Å)