6YKU

Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with Compound 11f

Summary for 6YKU

Entry DOI	10.2210/pdb6yku/pdb
Related	6YKL 6YKN 6YKO 6YKQ 6YKS 6YKT
Descriptor	Leucine--tRNA ligase, ZINC ION, [(2~{R},3~{S},4~{S},5~{R})-3,4-bis(oxidanyl)-5-[3-[4-[4-(trifluoromethyloxy)phenyl]-1,2,3-triazol-1-yl]propyl]oxan-2-yl]methyl ~{N}-[(2~{S})-2-azanyl-4-methyl-pentanoyl]sulfamate, ... (6 entities in total)
Functional Keywords	protein-inhibitor complex, rossmann fold, trna synthetase, ligase
Biological source	Neisseria gonorrhoeae
Total number of polymer chains	1
Total formula weight	99070.88
Authors	Pang, L.,Strelkov, S.V.,Weeks, S.D. (deposition date: 2020-04-06, release date: 2020-12-02, Last modification date: 2024-01-24)
Primary citation	De Ruysscher, D.,Pang, L.,Lenders, S.M.G.,Cappoen, D.,Cos, P.,Rozenski, J.,Strelkov, S.V.,Weeks, S.D.,Van Aerschot, A. Synthesis and structure-activity studies of novel anhydrohexitol-based Leucyl-tRNA synthetase inhibitors. Eur.J.Med.Chem., 211:113021-113021, 2021 Cited by PubMed: 33248851 DOI: 10.1016/j.ejmech.2020.113021 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.14 Å)

Structure validation