6YKQ
Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with Compound 11c
Summary for 6YKQ
Entry DOI | 10.2210/pdb6ykq/pdb |
Related | 6YKL 6YKN 6YKO |
Descriptor | Leucine--tRNA ligase, [(2~{R},3~{S},4~{S},5~{R})-5-[3-(4-octyl-1,2,3-triazol-1-yl)propyl]-3,4-bis(oxidanyl)oxan-2-yl]methyl ~{N}-[(2~{S})-2-azanyl-4-methyl-pentanoyl]sulfamate, ZINC ION, ... (6 entities in total) |
Functional Keywords | protein-inhibitor complex, rossmann fold, trna synthetase, ligase |
Biological source | Neisseria gonorrhoeae |
Total number of polymer chains | 1 |
Total formula weight | 99023.00 |
Authors | Pang, L.,Strelkov, S.V.,Weeks, S.D. (deposition date: 2020-04-06, release date: 2020-12-02, Last modification date: 2024-01-24) |
Primary citation | De Ruysscher, D.,Pang, L.,Lenders, S.M.G.,Cappoen, D.,Cos, P.,Rozenski, J.,Strelkov, S.V.,Weeks, S.D.,Van Aerschot, A. Synthesis and structure-activity studies of novel anhydrohexitol-based Leucyl-tRNA synthetase inhibitors. Eur.J.Med.Chem., 211:113021-113021, 2021 Cited by PubMed: 33248851DOI: 10.1016/j.ejmech.2020.113021 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.94 Å) |
Structure validation
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