6YKJ

Crystal structure of YTHDC1 with compound DHU_DC1_125

Summary for 6YKJ

Entry DOI	10.2210/pdb6ykj/pdb
Descriptor	YTHDC1, SULFATE ION, ~{N}-methyl-4-(methylamino)pyridine-2-carboxamide, ... (4 entities in total)
Functional Keywords	ythdc1, m6a, complex, inhibitor, rna binding protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	42745.02
Authors	Bedi, R.K.,Huang, D.,Wiedmer, L.,Caflisch, A. (deposition date: 2020-04-06, release date: 2020-07-15, Last modification date: 2024-01-24)
Primary citation	Li, Y.,Bedi, R.K.,Nai, F.,von Roten, V.,Dolbois, A.,Zalesak, F.,Nachawati, R.,Huang, D.,Caflisch, A. Structure-based design of ligands of the m6A-RNA reader YTHDC1 Eur J Med Chem Rep, 5:100057-, 2022 Cited by DOI: 10.1016/j.ejmcr.2022.100057 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation