6YID
Crystal structure of ULK2 in complex with SBI-0206965
6YID の概要
エントリーDOI | 10.2210/pdb6yid/pdb |
分子名称 | Serine/threonine-protein kinase ULK2, 2-({5-bromo-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}oxy)-N-methylbenzene-1-carboximidic acid (3 entities in total) |
機能のキーワード | kinase, kinase inhibitor, ulk2, autophagy, chemical probe, structural genomics, structural genomics consortium, sgc, transferase |
由来する生物種 | Homo sapiens (Human) |
タンパク質・核酸の鎖数 | 4 |
化学式量合計 | 129028.16 |
構造登録者 | Chaikuad, A.,Ren, H.,Bakas, N.A.,Lambert, L.J.,Cosford, N.D.P.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2020-04-01, 公開日: 2020-06-17, 最終更新日: 2024-01-24) |
主引用文献 | Ren, H.,Bakas, N.A.,Vamos, M.,Chaikuad, A.,Limpert, A.S.,Wimer, C.D.,Brun, S.N.,Lambert, L.J.,Tautz, L.,Celeridad, M.,Sheffler, D.J.,Knapp, S.,Shaw, R.J.,Cosford, N.D.P. Design, Synthesis, and Characterization of an Orally Active Dual-Specific ULK1/2 Autophagy Inhibitor that Synergizes with the PARP Inhibitor Olaparib for the Treatment of Triple-Negative Breast Cancer. J.Med.Chem., 63:14609-14625, 2020 Cited by PubMed: 33200929DOI: 10.1021/acs.jmedchem.0c00873 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.7 Å) |
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