6YBA

HAdV-F41 Capsid

6YBA の概要

• エントリーDOI: 10.2210/pdb6yba/pdb
• EMDBエントリー: 10768
• 分子名称: Hexon protein, Penton protein, Pre-hexon-linking protein IIIa, ... (7 entities in total)
• 機能のキーワード: adenovirus, virus
• 由来する生物種: Human adenovirus F serotype 41; 詳細
• タンパク質・核酸の鎖数: 26
• 化学式量合計: 1633376.97

構造登録者

Perez Illana, M.,Martinez, M.,Mangroo, C.,Brown, M.,Marabini, R.,San Martin, C. (登録日: 2020-03-16, 公開日: 2021-03-10, 最終更新日: 2024-05-22)

主引用文献

Perez-Illana, M.,Martinez, M.,Condezo, G.N.,Hernando-Perez, M.,Mangroo, C.,Brown, M.,Marabini, R.,San Martin, C.
Cryo-EM structure of enteric adenovirus HAdV-F41 highlights structural variations among human adenoviruses.
Sci Adv, 7:-, 2021

PubMed Abstract: Enteric adenoviruses, one of the main causes of viral gastroenteritis in the world, must withstand the harsh conditions found in the gut. This requirement suggests that capsid stability must be different from that of other adenoviruses. We report the 4-Å-resolution structure of a human enteric adenovirus, HAdV-F41, and compare it with that of other adenoviruses with respiratory (HAdV-C5) and ocular (HAdV-D26) tropisms. While the overall structures of hexon, penton base, and internal minor coat proteins IIIa and VIII are conserved, we observe partially ordered elements reinforcing the vertex region, which suggests their role in enhancing the physicochemical capsid stability of HAdV-F41. Unexpectedly, we find an organization of the external minor coat protein IX different from all previously characterized human and nonhuman mastadenoviruses. Knowledge of the structure of enteric adenoviruses provides a starting point for the design of vectors suitable for oral delivery or intestinal targeting.

PubMed: 33627423
DOI: 10.1126/sciadv.abd9421

実験手法

ELECTRON MICROSCOPY (4 Å)