6Y75

BIL2 domain from T.thermophila BUBL1 locus (C1A-N143A)

6Y75 の概要

• エントリーDOI: 10.2210/pdb6y75/pdb
• 分子名称: NAD(P)(+)--arginine ADP-ribosyltransferase, DI(HYDROXYETHYL)ETHER, ZINC ION, ... (6 entities in total)
• 機能のキーワード: intein, ptm, ubiquitin, splicing
• 由来する生物種: Tetrahymena thermophila (strain SB210); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 69978.34

構造登録者

Ilari, A.,Chiarini, V. (登録日: 2020-02-28, 公開日: 2021-02-03, 最終更新日: 2026-02-11)

主引用文献

Chiarini, V.,Fiorillo, A.,Camerini, S.,Crescenzi, M.,Nakamura, S.,Battista, T.,Guidoni, L.,Colotti, G.,Ilari, A.
Structural basis of ubiquitination mediated by protein splicing in early Eukarya.
Biochim Biophys Acta Gen Subj, 1865:129844-129844, 2021

PubMed Abstract: Inteins are intervening proteins, which are known to perform protein splicing. The reaction results in the production of an intein domain and an inteinless protein, which shows no trace of the insertion. BIL2 is part of the polyubiquitin locus of Tetrahymena thermophila (BUBL), where two bacterial-intein-like (BIL) domains lacking the C + 1 nucleophile, are flanked by two independent ubiquitin-like domains (ubl4/ubl5).

PubMed: 33444728
DOI: 10.1016/j.bbagen.2021.129844

実験手法

X-RAY DIFFRACTION (2.3 Å)