6Y6H

Crystal structure of STK17b (DRAK2) in complex with UNC-AP-194 probe

Summary for 6Y6H

Entry DOI	10.2210/pdb6y6h/pdb
Descriptor	Serine/threonine-protein kinase 17B, 2-[6-(1-benzothiophen-2-yl)thieno[3,2-d]pyrimidin-4-yl]sulfanylethanoic acid, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	kinase, kinase inhibitor, pkis, drak2, chemical probe, structural genomics, structural genomics consortium, sgc, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	37995.88
Authors	Chaikuad, A.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Drewry, D.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2020-02-26, release date: 2020-03-11, Last modification date: 2024-01-24)
Primary citation	Picado, A.,Chaikuad, A.,Wells, C.I.,Shrestha, S.,Zuercher, W.J.,Pickett, J.E.,Kwarcinski, F.E.,Sinha, P.,de Silva, C.S.,Zutshi, R.,Liu, S.,Kannan, N.,Knapp, S.,Drewry, D.H.,Willson, T.M. A Chemical Probe for Dark Kinase STK17B Derives Its Potency and High Selectivity through a Unique P-Loop Conformation. J.Med.Chem., 63:14626-14646, 2020 Cited by PubMed: 33215924 DOI: 10.1021/acs.jmedchem.0c01174 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation