6Y6H

Crystal structure of STK17b (DRAK2) in complex with UNC-AP-194 probe

6Y6H の概要

• エントリーDOI: 10.2210/pdb6y6h/pdb
• 分子名称: Serine/threonine-protein kinase 17B, 2-[6-(1-benzothiophen-2-yl)thieno[3,2-d]pyrimidin-4-yl]sulfanylethanoic acid, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: kinase, kinase inhibitor, pkis, drak2, chemical probe, structural genomics, structural genomics consortium, sgc, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37995.88

構造登録者

Chaikuad, A.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Drewry, D.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2020-02-26, 公開日: 2020-03-11, 最終更新日: 2024-01-24)

• 主引用文献: Picado, A.,Chaikuad, A.,Wells, C.I.,Shrestha, S.,Zuercher, W.J.,Pickett, J.E.,Kwarcinski, F.E.,Sinha, P.,de Silva, C.S.,Zutshi, R.,Liu, S.,Kannan, N.,Knapp, S.,Drewry, D.H.,Willson, T.M.; A Chemical Probe for Dark Kinase STK17B Derives Its Potency and High Selectivity through a Unique P-Loop Conformation.; J.Med.Chem., 63:14626-14646, 2020; PubMed: 33215924; DOI: 10.1021/acs.jmedchem.0c01174

実験手法

X-RAY DIFFRACTION (1.95 Å)