6Y5O
The crystal structure of glycogen phosphorylase in complex with 20
Summary for 6Y5O
Entry DOI | 10.2210/pdb6y5o/pdb |
Descriptor | Glycogen phosphorylase, muscle form, 2-(4-fluorophenyl)-5,7-bis(oxidanyl)chromen-4-one (3 entities in total) |
Functional Keywords | transferase, glycogen metabolism |
Biological source | Oryctolagus cuniculus (Rabbit) |
Total number of polymer chains | 1 |
Total formula weight | 97791.55 |
Authors | Kyriakis, E.,Koulas, S.M.,Skamnaki, V.T.,Leonidas, D.D. (deposition date: 2020-02-25, release date: 2020-08-19) |
Primary citation | Chetter, B.A.,Kyriakis, E.,Barr, D.,Karra, A.G.,Katsidou, E.,Koulas, S.M.,Skamnaki, V.T.,Snape, T.J.,Psarra, A.G.,Leonidas, D.D.,Hayes, J.M. Synthetic flavonoid derivatives targeting the glycogen phosphorylase inhibitor site: QM/MM-PBSA motivated synthesis of substituted 5,7-dihydroxyflavones, crystallography, in vitro kinetics and ex-vivo cellular experiments reveal novel potent inhibitors. Bioorg.Chem., 102:104003-104003, 2020 Cited by PubMed: 32771768DOI: 10.1016/j.bioorg.2020.104003 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.33 Å) |
Structure validation
Download full validation report