6Y55

The crystal structure of glycogen phosphorylase in complex with 43

6Y55 の概要

• エントリーDOI: 10.2210/pdb6y55/pdb
• 分子名称: Glycogen phosphorylase, muscle form, 2-(3-methylphenyl)-5,7-bis(oxidanyl)chromen-4-one (3 entities in total)
• 機能のキーワード: transferase, glycogen metabolism
• 由来する生物種: Oryctolagus cuniculus (Rabbit)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 97918.78

構造登録者

Kyriakis, E.,Koulas, S.M.,Skamnaki, V.T.,Leonidas, D.D. (登録日: 2020-02-24, 公開日: 2020-08-19)

• 主引用文献: Chetter, B.A.,Kyriakis, E.,Barr, D.,Karra, A.G.,Katsidou, E.,Koulas, S.M.,Skamnaki, V.T.,Snape, T.J.,Psarra, A.G.,Leonidas, D.D.,Hayes, J.M.; Synthetic flavonoid derivatives targeting the glycogen phosphorylase inhibitor site: QM/MM-PBSA motivated synthesis of substituted 5,7-dihydroxyflavones, crystallography, in vitro kinetics and ex-vivo cellular experiments reveal novel potent inhibitors.; Bioorg.Chem., 102:104003-104003, 2020; PubMed: 32771768; DOI: 10.1016/j.bioorg.2020.104003

実験手法

X-RAY DIFFRACTION (2.38 Å)