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6Y4U

Crystal structure of p38 in complex with SR65

Summary for 6Y4U
Entry DOI10.2210/pdb6y4u/pdb
DescriptorMitogen-activated protein kinase 14, 5-azanyl-~{N}-[[4-[[(2~{S})-4-cyclohexyl-1-oxidanylidene-1-(pentan-3-ylamino)butan-2-yl]carbamoyl]phenyl]methyl]-1-phenyl-pyrazole-4-carboxamide, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywordskinase, kinase inhibitor, mapk14, mapk, structural genomics, structural genomics consortium, sgc, transferase
Biological sourceMus musculus (House mouse)
Total number of polymer chains1
Total formula weight42216.22
Authors
Chaikuad, A.,Roehm, S.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2020-02-23, release date: 2020-03-04, Last modification date: 2024-01-24)
Primary citationRohm, S.,Schroder, M.,Dwyer, J.E.,Widdowson, C.S.,Chaikuad, A.,Berger, B.T.,Joerger, A.C.,Kramer, A.,Harbig, J.,Dauch, D.,Kudolo, M.,Laufer, S.,Bagley, M.C.,Knapp, S.
Selective targeting of the alpha C and DFG-out pocket in p38 MAPK.
Eur.J.Med.Chem., 208:112721-112721, 2020
Cited by
PubMed: 33035818
DOI: 10.1016/j.ejmech.2020.112721
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.86 Å)
Structure validation

217705

数据于2024-03-27公开中

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