6Y4U

Crystal structure of p38 in complex with SR65

6Y4U の概要

• エントリーDOI: 10.2210/pdb6y4u/pdb
• 分子名称: Mitogen-activated protein kinase 14, 5-azanyl-~{N}-[[4-[[(2~{S})-4-cyclohexyl-1-oxidanylidene-1-(pentan-3-ylamino)butan-2-yl]carbamoyl]phenyl]methyl]-1-phenyl-pyrazole-4-carboxamide, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: kinase, kinase inhibitor, mapk14, mapk, structural genomics, structural genomics consortium, sgc, transferase
• 由来する生物種: Mus musculus (House mouse)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42216.22

構造登録者

Chaikuad, A.,Roehm, S.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2020-02-23, 公開日: 2020-03-04, 最終更新日: 2024-01-24)

• 主引用文献: Rohm, S.,Schroder, M.,Dwyer, J.E.,Widdowson, C.S.,Chaikuad, A.,Berger, B.T.,Joerger, A.C.,Kramer, A.,Harbig, J.,Dauch, D.,Kudolo, M.,Laufer, S.,Bagley, M.C.,Knapp, S.; Selective targeting of the alpha C and DFG-out pocket in p38 MAPK.; Eur.J.Med.Chem., 208:112721-112721, 2020; PubMed: 33035818; DOI: 10.1016/j.ejmech.2020.112721

実験手法

X-RAY DIFFRACTION (1.86 Å)