6Y3U

Crystal structure of PPARgamma in complex with compound (R)-16

Summary for 6Y3U

Entry DOI	10.2210/pdb6y3u/pdb
Descriptor	Peroxisome proliferator-activated receptor gamma, (2~{R})-2-[[6-[(2,4-dichlorophenyl)sulfonylamino]-1,3-benzothiazol-2-yl]sulfanyl]octanoic acid (3 entities in total)
Functional Keywords	nuclear receptor, inhibitor, steroid hormone receptor, structural genomics consortium, sgc, transcription
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	32201.30
Authors	Chaikuad, A.,Hanke, T.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Merk, D.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2020-02-18, release date: 2020-04-22, Last modification date: 2024-01-24)
Primary citation	Hanke, T.,Cheung, S.Y.,Kilu, W.,Heering, J.,Ni, X.,Planz, V.,Schierle, S.,Faudone, G.,Friedrich, M.,Wanior, M.,Werz, O.,Windbergs, M.,Proschak, E.,Schubert-Zsilavecz, M.,Chaikuad, A.,Knapp, S.,Merk, D. A Selective Modulator of Peroxisome Proliferator-Activated Receptor gamma with an Unprecedented Binding Mode. J.Med.Chem., 63:4555-4561, 2020 Cited by PubMed: 32267688 DOI: 10.1021/acs.jmedchem.9b01786 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.62 Å)

Structure validation