6Y3U

Crystal structure of PPARgamma in complex with compound (R)-16

6Y3U の概要

• エントリーDOI: 10.2210/pdb6y3u/pdb
• 分子名称: Peroxisome proliferator-activated receptor gamma, (2~{R})-2-[[6-[(2,4-dichlorophenyl)sulfonylamino]-1,3-benzothiazol-2-yl]sulfanyl]octanoic acid (3 entities in total)
• 機能のキーワード: nuclear receptor, inhibitor, steroid hormone receptor, structural genomics consortium, sgc, transcription
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 32201.30

構造登録者

Chaikuad, A.,Hanke, T.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Merk, D.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2020-02-18, 公開日: 2020-04-22, 最終更新日: 2024-01-24)

• 主引用文献: Hanke, T.,Cheung, S.Y.,Kilu, W.,Heering, J.,Ni, X.,Planz, V.,Schierle, S.,Faudone, G.,Friedrich, M.,Wanior, M.,Werz, O.,Windbergs, M.,Proschak, E.,Schubert-Zsilavecz, M.,Chaikuad, A.,Knapp, S.,Merk, D.; A Selective Modulator of Peroxisome Proliferator-Activated Receptor gamma with an Unprecedented Binding Mode.; J.Med.Chem., 63:4555-4561, 2020; PubMed: 32267688; DOI: 10.1021/acs.jmedchem.9b01786

実験手法

X-RAY DIFFRACTION (2.62 Å)