6Y1M

Crystal structure of the paraoxon-modified A.17 antibody FAB fragment - L47K mutant

6Y1M の概要

• エントリーDOI: 10.2210/pdb6y1m/pdb
• 分子名称: FAB A.17 L47K mutant HEAVY CHAIN, FAB A.17 L47K mutant Light CHAIN, DIETHYL PHOSPHONATE, ... (4 entities in total)
• 機能のキーワード: qm/mm computation; designed biocatalysts; bioscavengers; phosphoryl transfer; organophosphorus agents, immune system
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 54159.65

構造登録者

Chatziefthimiou, S.,Mokrushina, Y.,Smirnov, I.,Gabibov, A.,Wilmanns, M. (登録日: 2020-02-12, 公開日: 2020-09-16, 最終更新日: 2024-01-24)

• 主引用文献: Mokrushina, Y.A.,Golovin, A.V.,Smirnov, I.V.,Chatziefthimiou, S.D.,Stepanova, A.V.,Bobik, T.V.,Zalevsky, A.O.,Zlobin, A.S.,Konovalov, K.A.,Terekhov, S.S.,Stepanov, A.V.,Pipiya, S.O.,Shamborant, O.G.,Round, E.,Belogurov Jr., A.A.,Bourenkov, G.,Makarov, A.A.,Wilmanns, M.,Xie, J.,Blackburn, G.M.,Gabibov, A.G.,Lerner, R.A.; Multiscale computation delivers organophosphorus reactivity and stereoselectivity to immunoglobulin scavengers.; Proc.Natl.Acad.Sci.USA, 117:22841-22848, 2020; PubMed: 32859757; DOI: 10.1073/pnas.2010317117

実験手法

X-RAY DIFFRACTION (2 Å)