6XY2

Crystal structure of CTLA-4 complexed with the Fab of HL32 antibody

Summary for 6XY2

Entry DOI	10.2210/pdb6xy2/pdb
Descriptor	Cytotoxic T-lymphocyte protein 4, Heavy chain, Light chain, ... (4 entities in total)
Functional Keywords	ctla-4, fab, antibody, immunnotherapy, immune system
Biological source	Homo sapiens (Human) More
Total number of polymer chains	3
Total formula weight	63503.82
Authors	Gao, H.,Zhou, A. (deposition date: 2020-01-29, release date: 2020-12-09, Last modification date: 2024-01-24)
Primary citation	Gao, H.,Cai, H.,Liu, J.,Wang, X.,Zheng, P.,Devenport, M.,Xu, T.,Dou, F.,Liu, Y.,Zhou, A. Structure of CTLA-4 complexed with a pH-sensitive cancer immunotherapeutic antibody. Cell Discov, 6:79-79, 2020 Cited by PubMed: 33298884 DOI: 10.1038/s41421-020-00202-9 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.05 Å)

Structure validation