6XX2

Crystal structure of the c-Src SH3 domain H122R-Q128K mutant in complex with Cu(II) at pH 7.5 co-crystallized with methyl beta-cyclodextrin

Summary for 6XX2

• Entry DOI: 10.2210/pdb6xx2/pdb
• Related PRD ID: PRD_900086
• Descriptor: Proto-oncogene tyrosine-protein kinase Src, Cyclic 2,3-di-O-methyl-alpha-D-glucopyranose-(1-4)-2-O-methyl-alpha-D-glucopyranose-(1-4)-2,6-di-O-methyl-alpha-D-glucopyranose-(1-4)-2-O-methyl-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-3-O-methyl-alpha-D-glucopyranose, COPPER (II) ION, ... (4 entities in total)
• Functional Keywords: beta barrel, sh3 domain, protein binding
• Biological source: Gallus gallus (Chicken)
• Total number of polymer chains: 1
• Total formula weight: 8240.33

Authors

Camara-Artigas, A. (deposition date: 2020-01-26, release date: 2020-04-22, Last modification date: 2024-01-24)

• Primary citation: Plaza-Garrido, M.,Salinas-Garcia, M.C.,Martinez, J.C.,Camara-Artigas, A.; The effect of an engineered ATCUN motif on the structure and biophysical properties of the SH3 domain of c-Src tyrosine kinase.; J.Biol.Inorg.Chem., 25:621-634, 2020; PubMed: 32279137; DOI: 10.1007/s00775-020-01785-0

Experimental method

X-RAY DIFFRACTION (1.25 Å)