6XX2

Crystal structure of the c-Src SH3 domain H122R-Q128K mutant in complex with Cu(II) at pH 7.5 co-crystallized with methyl beta-cyclodextrin

6XX2 の概要

• エントリーDOI: 10.2210/pdb6xx2/pdb
• 関連するBIRD辞書のPRD_ID: PRD_900086
• 分子名称: Proto-oncogene tyrosine-protein kinase Src, Cyclic 2,3-di-O-methyl-alpha-D-glucopyranose-(1-4)-2-O-methyl-alpha-D-glucopyranose-(1-4)-2,6-di-O-methyl-alpha-D-glucopyranose-(1-4)-2-O-methyl-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-3-O-methyl-alpha-D-glucopyranose, COPPER (II) ION, ... (4 entities in total)
• 機能のキーワード: beta barrel, sh3 domain, protein binding
• 由来する生物種: Gallus gallus (Chicken)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 8240.33

構造登録者

Camara-Artigas, A. (登録日: 2020-01-26, 公開日: 2020-04-22, 最終更新日: 2024-01-24)

• 主引用文献: Plaza-Garrido, M.,Salinas-Garcia, M.C.,Martinez, J.C.,Camara-Artigas, A.; The effect of an engineered ATCUN motif on the structure and biophysical properties of the SH3 domain of c-Src tyrosine kinase.; J.Biol.Inorg.Chem., 25:621-634, 2020; PubMed: 32279137; DOI: 10.1007/s00775-020-01785-0

実験手法

X-RAY DIFFRACTION (1.25 Å)