6XWE

Crystal structure of LYK3 ectodomain

6XWE の概要

• エントリーDOI: 10.2210/pdb6xwe/pdb
• 分子名称: LysM domain receptor-like kinase 3, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: lysm, receptor, symbiosis, plant protein
• 由来する生物種: Medicago truncatula (Barrel medic)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 25264.40

構造登録者

Gysel, K.,Blaise, M.,Andersen, K.R. (登録日: 2020-01-23, 公開日: 2020-08-12, 最終更新日: 2024-10-23)

主引用文献

Bozsoki, Z.,Gysel, K.,Hansen, S.B.,Lironi, D.,Kronauer, C.,Feng, F.,de Jong, N.,Vinther, M.,Kamble, M.,Thygesen, M.B.,Engholm, E.,Kofoed, C.,Fort, S.,Sullivan, J.T.,Ronson, C.W.,Jensen, K.J.,Blaise, M.,Oldroyd, G.,Stougaard, J.,Andersen, K.R.,Radutoiu, S.
Ligand-recognizing motifs in plant LysM receptors are major determinants of specificity.
Science, 369:663-670, 2020

PubMed Abstract: Plants evolved lysine motif (LysM) receptors to recognize and parse microbial elicitors and drive intracellular signaling to limit or facilitate microbial colonization. We investigated how chitin and nodulation (Nod) factor receptors of initiate differential signaling of immunity or root nodule symbiosis. Two motifs in the LysM1 domains of these receptors determine specific recognition of ligands and discriminate between their in planta functions. These motifs define the ligand-binding site and make up the most structurally divergent regions in cognate Nod factor receptors. An adjacent motif modulates the specificity for Nod factor recognition and determines the selection of compatible rhizobial symbionts in legumes. We also identified how binding specificities in LysM receptors can be altered to facilitate Nod factor recognition and signaling from a chitin receptor, advancing the prospects of engineering rhizobial symbiosis into nonlegumes.

PubMed: 32764065
DOI: 10.1126/science.abb3377

実験手法

X-RAY DIFFRACTION (1.49 Å)