6XV1
Human Sirt6 13-308 in complex with ADP-ribose and the activator MDL-801
Summary for 6XV1
| Entry DOI | 10.2210/pdb6xv1/pdb |
| Descriptor | NAD-dependent protein deacetylase sirtuin-6, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE, ZINC ION, ... (6 entities in total) |
| Functional Keywords | deacylase, activator, allosteric, isoform-selective, hydrolase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 2 |
| Total formula weight | 69893.41 |
| Authors | You, W.,Steegborn, C. (deposition date: 2020-01-21, release date: 2020-10-28, Last modification date: 2024-01-24) |
| Primary citation | You, W.,Steegborn, C. Binding site for activator MDL-801 on SIRT6. Nat.Chem.Biol., 17:519-521, 2021 Cited by PubMed: 33649599DOI: 10.1038/s41589-021-00749-y PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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