6XUU

Crystallographic structure of oligosaccharide dehydrogenase from Pycnoporus cinnabarinus, glucose-bound form

6XUU の概要

• エントリーDOI: 10.2210/pdb6xuu/pdb
• 関連するPDBエントリー: 6XUT
• 分子名称: Oligosaccharide dehydrogenase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, FLAVIN-ADENINE DINUCLEOTIDE, ... (8 entities in total)
• 機能のキーワード: glucose dehydrogenase, pycnoporus cinnabarinus, glucose, oxidoreductase, oligosaccharide dehydrogenase
• 由来する生物種: Pycnoporus cinnabarinus (Cinnabar-red polypore)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 66421.73

構造登録者

Cerutti, G.,Savino, C.,Montemiglio, L.C.,Vallone, B.,Sciara, G. (登録日: 2020-01-21, 公開日: 2021-02-03, 最終更新日: 2024-10-23)

主引用文献

Cerutti, G.,Gugole, E.,Montemiglio, L.C.,Turbe-Doan, A.,Chena, D.,Navarro, D.,Lomascolo, A.,Piumi, F.,Exertier, C.,Freda, I.,Vallone, B.,Record, E.,Savino, C.,Sciara, G.
Crystal structure and functional characterization of an oligosaccharide dehydrogenase from Pycnoporus cinnabarinus provides insights into fungal breakdown of lignocellulose.
Biotechnol Biofuels, 14:161-161, 2021

PubMed Abstract: Fungal glucose dehydrogenases (GDHs) are FAD-dependent enzymes belonging to the glucose-methanol-choline oxidoreductase superfamily. These enzymes are classified in the "Auxiliary Activity" family 3 (AA3) of the Carbohydrate-Active enZymes database, and more specifically in subfamily AA3_2, that also includes the closely related flavoenzymes aryl-alcohol oxidase and glucose 1-oxidase. Based on sequence similarity to known fungal GDHs, an AA3_2 enzyme active on glucose was identified in the genome of Pycnoporus cinnabarinus, a model Basidiomycete able to completely degrade lignin.

PubMed: 34294139
DOI: 10.1186/s13068-021-02003-y

実験手法

X-RAY DIFFRACTION (1.57 Å)