6XUE

Human Ecto-5'-nucleotidase (CD73) in complex with A2396 (compound 74 in publication) in the closed form in crystal form IV

6XUE の概要

• エントリーDOI: 10.2210/pdb6xue/pdb
• 分子名称: 5'-nucleotidase, ZINC ION, CALCIUM ION, ... (6 entities in total)
• 機能のキーワード: non-nucleotide inhibitor, hydrolase, arcus biosciences
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 120322.45

構造登録者

Strater, N. (登録日: 2020-01-19, 公開日: 2020-04-22, 最終更新日: 2024-01-24)

• 主引用文献: Beatty, J.W.,Lindsey, E.A.,Thomas-Tran, R.,Debien, L.,Mandal, D.,Jeffrey, J.L.,Tran, A.T.,Fournier, J.,Jacob, S.D.,Yan, X.,Drew, S.L.,Ginn, E.,Chen, A.,Pham, A.T.,Zhao, S.,Jin, L.,Young, S.W.,Walker, N.P.,Leleti, M.R.,Moschutz, S.,Strater, N.,Powers, J.P.,Lawson, K.V.; Discovery of Potent and Selective Non-Nucleotide Small Molecule Inhibitors of CD73.; J.Med.Chem., 63:3935-3955, 2020; PubMed: 32212732; DOI: 10.1021/acs.jmedchem.9b01713

実験手法

X-RAY DIFFRACTION (1.94 Å)