6XS8

Crystal structure of Chaetomium thermophilum Vps29 complexed with RaPID-derived cyclic peptide RT-D3

Summary for 6XS8

• Entry DOI: 10.2210/pdb6xs8/pdb
• Related: 6XS5 6XS7
• Descriptor: Vacuolar protein sorting-associated protein 29, 48V-DTY-GLY-TYR-ASP-PRO-LEU-GLY-LEU-LYS-TYR-PHE-ALA (3 entities in total)
• Functional Keywords: vps29, retromer, endosome, protein transport, cyclic peptide, inhibitor, protein transport-inhibitor complex, protein transport/inhibitor
• Biological source: Chaetomium thermophilum; More
• Total number of polymer chains: 2
• Total formula weight: 23955.44

Authors

Chen, K.-E.,Guo, Q.,Collins, B.M. (deposition date: 2020-07-15, release date: 2021-07-14, Last modification date: 2023-10-18)

• Primary citation: Chen, K.E.,Guo, Q.,Hill, T.A.,Cui, Y.,Kendall, A.K.,Yang, Z.,Hall, R.J.,Healy, M.D.,Sacharz, J.,Norwood, S.J.,Fonseka, S.,Xie, B.,Reid, R.C.,Leneva, N.,Parton, R.G.,Ghai, R.,Stroud, D.A.,Fairlie, D.P.,Suga, H.,Jackson, L.P.,Teasdale, R.D.,Passioura, T.,Collins, B.M.; De novo macrocyclic peptides for inhibiting, stabilizing, and probing the function of the retromer endosomal trafficking complex.; Sci Adv, 7:eabg4007-eabg4007, 2021; PubMed: 34851660; DOI: 10.1126/sciadv.abg4007

Experimental method

X-RAY DIFFRACTION (1.95009854987 Å)